By: Perry Coleman
Who ever thought that chewing gum could become one of the choice delivery methods to achieve the benefits offered by Cannabidiol (CBD) and the many other cannabinoids of the cannabis plant? Well, luckily for those wishing to utilize this socially acceptable delivery method, the developers of CanChew Gum did.
Around 2008, the pharmaceutical company Sanammad Foundation was founded in the Netherlands where Dr. Phillip VanDamme, Dr. George Anastassov and Lekhram Changoer began work to focus on the treatment of pain and other medical disorders using cannabis/cannabinoids. Their choice delivery method would be chewing gum based products because of the rapid absorption capability gained by bypassing the intestinal tract and liver. Excited about their achievements, they then contacted Medical Marijuana Inc. to explore expansion opportunities.
Joint Venture Evolves into CanChew Biotechnologies Inc
After much work and success the company had come up with the CanChew product. Sanammad and Medical Marijuana, Inc’s (MJNA) then formed a joint venture (JV) in April 2012 with MJNA acquiring a 50% stake in the new company to create CanChew Biotechnologies. CanChew Biotechnologies then formed a wholly-owned subsidiary, CannaGum Marketing Group for the purpose of marketing and selling CanChew gum with hemp-based cannabinoids, specifically CBD. CanChew gum is for sale now and can be purchased at the company website (www.canchewgum.com). The site does not offer any medical claims associated with sales and provide full FDA disclosure.
CanChew Biotechnologies Inc then created MedChew RX which is presently undergoing its pre-clinical work for the formal clinical trials starting this year in Europe for treatments of pain, multiple sclerosis and other indications.
CanChew Gum is truly a unique product in that it is the first ever gum to contain CBD. CBD is a naturally occurring cannabinoid that provides for a host of benefits that includes chronic pain, anxiety, and inflammation. See US Patent # 6,630,570.
It’s even showing promise to be an effective anti-cancer drug. To quote from Dr McAllister: “Importantly, we have recently discovered that CBD, a nontoxic cannabinoid that lacks psycho-activity, can inhibit Id-1 gene expression in metastatic breast cancer cells and consequently their aggressive phenotype. The full research report can be found here.
Pain: A UCSF Study Finds Medical Marijuana Could Help Patients Reduce Pain with Opiates. CBD is “a major non-psychoactive component of cannabis that helps shrink inflammation and reduces pain without inducing the euphoria effects of THC. It has been used to treat rheumatoid arthritis, inflammatory bowel diseases, psychotic disorders and epilepsy. Larger amounts of CBD can relax the mind and body without causing negative side effects associated with THC.”
Anxiety: A preliminary report published in the Journal of Psychopharmacology Jan 2011 titled the “Neural basis of anxiolytic effects of CBD in generalized social anxiety disorder” states that studies indicate that CBD “has anxiolytic properties.
Sleep: CBD has even been shown to modulate sleep in rats by increasing wakefulness and reducing REM sleep during “lights-on” phases of the testing. The report is titled Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
Multiple Sclerosis MS: Research shows that CBD compounds have been shown to improve the symptoms of multiple sclerosis in animal models and clinical trials. CBD affected the progression of the disease through decreased inflammation, neuronal protection, and decreased immune cell activity.
The research report that discusses this, “Scientists Uncover How CBD Treats MS, Alters Cholesterol Metabolism”, goes on to discuss the beneficial effects of CBD on cholesterol.
Cholesterol: Genetic details reveal that “CBD can affect the genes Soat2 and Cyp27a1, which control sterol metabolism (Ex. Cholesterol). These are part of a larger group of genes, known as stress genes”. Research has also shown that CBD can increase the amount of Anandamide, a natural cannabinoid neurotransmitter mammals make from lipids. It is thought to be the “natural THC” found in our brains and throughout and bodies. The last 45 years has revealed that it is possible to demonstrate that CBD has a wide range of pharmacological effects that are of therapeutic interest, but validation of the benefits will still have to be proven through clinical trials.
Essentially this allows the information signals to brain to be better managed. This can translate into negative indications such as pain being muted or positive effects such as increasing appetite to be enhanced.
Actually increasing appetite is more associated with THC, the cannabinoid that provides the psychotropic (high) effect associated with marijuana. CBD is non-psychoactive, so the benefits can be realized without the medicating effects of THC.
Legal in the US
What’s great about CBD is that it’s legal in the United States when contained within hemp oil. CanChew Gum actually contains 50mg of CBD-rich hemp oil – that same hemp oil contains 10mg of CBD. CBD continues to gain popularity among those looking for better alternatives to pain management. I believe that this novel approach using gum as a delivery method will become increasingly more popular.
Other off the shelf hemp oils contain very little CBD. CanChew Biotechnologies analysis shows that it would take 5 of the 8 oz. bottles of hemp oil (at a cost of $40) to equate to the CBD in 1 piece of CanChew gum (10 mgs). Store bought hemp oil basically contains 10 mg CBD per kilogram as shown in Table 1. Hemp Seed Oil Macrocomposition on page 41 of the linked document. For synthetic CBD, Cayman Chemical charges $23 per milligram and Tocris BioScience has availability at $135 per 10 mgs
MJNA and its family of companies have many innovative products and CanChew is proving to be another great offering. While those interested in the company as an investment can purchase the company’s stock, entrepreneurs can participate through the company’s new affiliate and wholesalers programs that are just recently coming on line.
Take a look at what these synergistic companies are doing. It’s always interesting when technology and innovation meet opportunity.
Disclosure: I am long MJNA and this article was written on behalf of Medical Marijuana, Inc.
Source: Perry Coleman